Drug therapy monitoring (TDM) of Digoxin: safety and efficacy review
نویسندگان
چکیده
Digoxin was developed as a novel medication for the treatment of heart failure and atrial fibrillation (AF) 200 years ago. This investigation began with PubMed Google Scholar search various papers using terms digoxin safety efficacy, in failure, fibrillation. should be administered at dose 0.5–0.7 ng/mL individuals reduced ejection fraction. to decrease hospital readmissions, although SDC, creatinine, potassium levels continuously maintained limit risk toxicity. may used conjunction diuretics, spironolactone, ACE inhibitors, or beta-blockers. It is preferable take on regular basis. not pre-excitation syndrome because it can result rapid development accessory route conductors, which finally ventricular Due narrow therapeutic index digoxin, requires appropriate continuous monitoring.
منابع مشابه
ABC of monitoring drug therapy. Digoxin.
The plasma digoxin concentration that will result from a given dose of the drug can be predicted at best with only 34% accuracy, although knowledge of a previous concentration improves the ability to predict subsequent concentrations. In outpatients taking a fixed daily dosage, a steady state plasma digoxin concentrations vary widely (between 0 5 and 3 5 nmol/l). This means that if a target pla...
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The aim of our study was to determine the criteria and key factors for the effectiveness of digoxin therapy. A prospective opened-type study was carried out in conditions of everyday clinical practice. The concentrations of digoxin were quantified from blood samples taken following the achievement of drug steady-state (using AxSYM microparticle enzyme immunoassay-MEIA). The risk/benefit ratio w...
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OBJECTIVE To clarify the impact of digoxin on death and clinical outcomes across all observational and randomised controlled trials, accounting for study designs and methods. DATA SOURCES AND STUDY SELECTION Comprehensive literature search of Medline, Embase, the Cochrane Library, reference lists, and ongoing studies according to a prospectively registered design ( PROSPERO CRD42014010783),...
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ژورنال
عنوان ژورنال: ????????
سال: 2022
ISSN: ['2411-6076', '2709-135X']
DOI: https://doi.org/10.3897/pharmacia.69.e81467